diff --git a/wp-admin/includes/admin-filters.php b/wp-admin/includes/admin-filters.php
index 7b491c36b7..d03881c8ac 100644
--- a/wp-admin/includes/admin-filters.php
+++ b/wp-admin/includes/admin-filters.php
@@ -114,6 +114,7 @@ add_action( 'load-plugins.php', 'wp_plugin_update_rows', 20 ); // After wp_updat
 add_action( 'load-themes.php', 'wp_theme_update_rows', 20 ); // After wp_update_themes() is called.
 
 add_action( 'admin_notices', 'update_nag', 3 );
+add_action( 'admin_notices', 'deactivated_plugins_notice', 5 );
 add_action( 'admin_notices', 'paused_plugins_notice', 5 );
 add_action( 'admin_notices', 'paused_themes_notice', 5 );
 add_action( 'admin_notices', 'maintenance_nag', 10 );
diff --git a/wp-admin/includes/plugin.php b/wp-admin/includes/plugin.php
index 2b77846f8b..6e332c247e 100644
--- a/wp-admin/includes/plugin.php
+++ b/wp-admin/includes/plugin.php
@@ -2473,3 +2473,88 @@ function paused_plugins_notice() {
 		__( 'Go to the Plugins screen' )
 	);
 }
+
+/**
+ * Renders an admin notice when a plugin was deactivated during an update.
+ *
+ * Displays an admin notice in case a plugin has been deactivated during an
+ * upgrade due to incompatibility with the current version of WordPress.
+ *
+ * @since 5.8.0
+ * @access private
+ *
+ * @global string $pagenow
+ * @global string $wp_version
+ */
+function deactivated_plugins_notice() {
+	if ( 'plugins.php' === $GLOBALS['pagenow'] ) {
+		return;
+	}
+
+	if ( ! current_user_can( 'activate_plugins' ) ) {
+		return;
+	}
+
+	$blog_deactivated_plugins = get_option( 'wp_force_deactivated_plugins' );
+	$site_deactivated_plugins = array();
+
+	if ( false === $blog_deactivated_plugins ) {
+		// Option not in database, add an empty array to avoid extra DB queries on subsequent loads.
+		update_option( 'wp_force_deactivated_plugins', array() );
+	}
+
+	if ( is_multisite() ) {
+		$site_deactivated_plugins = get_site_option( 'wp_force_deactivated_plugins' );
+		if ( false === $site_deactivated_plugins ) {
+			// Option not in database, add an empty array to avoid extra DB queries on subsequent loads.
+			update_site_option( 'wp_force_deactivated_plugins', array() );
+		}
+	}
+
+	if ( empty( $blog_deactivated_plugins ) && empty( $site_deactivated_plugins ) ) {
+		// No deactivated plugins.
+		return;
+	}
+
+	$deactivated_plugins = array_merge( $blog_deactivated_plugins, $site_deactivated_plugins );
+
+	foreach ( $deactivated_plugins as $plugin ) {
+		if ( ! empty( $plugin['version_compatible'] ) && ! empty( $plugin['version_deactivated'] ) ) {
+			$explanation = sprintf(
+				/* translators: 1: Name of deactivated plugin, 2: Plugin version deactivated, 3: Current WP version, 4: Compatible plugin version */
+				__( '%1$s %2$s was deactivated due to incompatibility with WordPress %3$s, please upgrade to %1$s %4$s or later.' ),
+				$plugin['plugin_name'],
+				$plugin['version_deactivated'],
+				$GLOBALS['wp_version'],
+				$plugin['version_compatible']
+			);
+		} else {
+			$explanation = sprintf(
+				/* translators: 1: Name of deactivated plugin, 2: Plugin version deactivated, 3: Current WP version */
+				__( '%1$s %2$s was deactivated due to incompatibility with WordPress %3$s.' ),
+				$plugin['plugin_name'],
+				! empty( $plugin['version_deactivated'] ) ? $plugin['version_deactivated'] : '',
+				$GLOBALS['wp_version'],
+				$plugin['version_compatible']
+			);
+		}
+
+		printf(
+			'<div class="notice notice-warning"><p><strong>%s</strong><br>%s</p><p><a href="%s">%s</a></p></div>',
+			sprintf(
+				/* translators: %s: Name of deactivated plugin */
+				__( '%s plugin deactivated during WordPress upgrade.' ),
+				$plugin['plugin_name']
+			),
+			$explanation,
+			esc_url( admin_url( 'plugins.php?plugin_status=inactive' ) ),
+			__( 'Go to the Plugins screen' )
+		);
+	}
+
+	// Empty the options.
+	update_option( 'wp_force_deactivated_plugins', array() );
+	if ( is_multisite() ) {
+		update_site_option( 'wp_force_deactivated_plugins', array() );
+	}
+}
diff --git a/wp-admin/includes/schema.php b/wp-admin/includes/schema.php
index 6f528f2288..8b1e56f3af 100644
--- a/wp-admin/includes/schema.php
+++ b/wp-admin/includes/schema.php
@@ -542,6 +542,9 @@ function populate_options( array $options = array() ) {
 		// Default to enabled for new installs.
 		// See https://core.trac.wordpress.org/ticket/51742.
 		'auto_update_core_major'          => 'enabled',
+
+		// 5.8.0
+		'wp_force_deactivated_plugins'    => array(),
 	);
 
 	// 3.3.0
diff --git a/wp-admin/includes/update-core.php b/wp-admin/includes/update-core.php
index 32c70a19f0..8e83c4a4ce 100644
--- a/wp-admin/includes/update-core.php
+++ b/wp-admin/includes/update-core.php
@@ -1672,6 +1672,20 @@ function _upgrade_440_force_deactivate_incompatible_plugins() {
  */
 function _upgrade_580_force_deactivate_incompatible_plugins() {
 	if ( defined( 'GUTENBERG_VERSION' ) && version_compare( GUTENBERG_VERSION, '10.7', '<=' ) ) {
+		$deactivated_gutenberg['gutenberg'] = array(
+			'plugin_name'         => 'Gutenberg',
+			'version_deactivated' => GUTENBERG_VERSION,
+			'version_compatible'  => '10.8',
+		);
+		if ( is_plugin_active_for_network( 'gutenberg/gutenberg.php' ) ) {
+			$deactivated_plugins = get_site_option( 'wp_force_deactivated_plugins', array() );
+			$deactivated_plugins = array_merge( $deactivated_plugins, $deactivated_gutenberg );
+			update_site_option( 'wp_force_deactivated_plugins', $deactivated_plugins );
+		} else {
+			$deactivated_plugins = get_option( 'wp_force_deactivated_plugins', array() );
+			$deactivated_plugins = array_merge( $deactivated_plugins, $deactivated_gutenberg );
+			update_option( 'wp_force_deactivated_plugins', $deactivated_plugins );
+		}
 		deactivate_plugins( array( 'gutenberg/gutenberg.php' ), true );
 	}
 }
diff --git a/wp-includes/version.php b/wp-includes/version.php
index 4fbc390735..bb172dc5b8 100644
--- a/wp-includes/version.php
+++ b/wp-includes/version.php
@@ -13,7 +13,7 @@
  *
  * @global string $wp_version
  */
-$wp_version = '5.8-beta4-51265';
+$wp_version = '5.8-beta4-51266';
 
 /**
  * Holds the WordPress DB revision, increments when changes are made to the WordPress DB schema.