diff --git a/wp-includes/functions.php b/wp-includes/functions.php
index 1693c13e7f..60dd4bda3c 100644
--- a/wp-includes/functions.php
+++ b/wp-includes/functions.php
@@ -3250,9 +3250,9 @@ function wp_die( $message = '', $title = '', $args = array() ) {
 		 * @param callable $function Callback function name.
 		 */
 		$function = apply_filters( 'wp_die_json_handler', '_json_wp_die_handler' );
-	} elseif ( wp_is_jsonp_request() ) {
+	} elseif ( defined( 'REST_REQUEST' ) && REST_REQUEST && wp_is_jsonp_request() ) {
 		/**
-		 * Filters the callback for killing WordPress execution for JSONP requests.
+		 * Filters the callback for killing WordPress execution for JSONP REST requests.
 		 *
 		 * @since 5.2.0
 		 *