diff --git a/src/main/java/com/sk89q/worldguard/bukkit/WorldGuardEntityListener.java b/src/main/java/com/sk89q/worldguard/bukkit/WorldGuardEntityListener.java
index 20df8ed7..149589b7 100644
--- a/src/main/java/com/sk89q/worldguard/bukkit/WorldGuardEntityListener.java
+++ b/src/main/java/com/sk89q/worldguard/bukkit/WorldGuardEntityListener.java
@@ -236,18 +236,12 @@ private void onEntityDamageByEntity(EntityDamageByEntityEvent event) {
                     }
                 }
             }
+        }
 
-            if (defender instanceof ItemFrame && wcfg.useRegions) {
-                // bukkit throws this event when a player attempts to remove an item from a frame
-                World world = player.getWorld();
-                RegionManager mgr = plugin.getGlobalRegionManager().get(world);
-                if (!plugin.getGlobalRegionManager().hasBypass(player, world)
-                        && !mgr.getApplicableRegions(defender.getLocation())
-                                .canBuild(plugin.wrapPlayer(player))) {
-                    player.sendMessage(ChatColor.DARK_RED + "You don't have permission for this area.");
-                    event.setCancelled(true);
-                    return;
-                }
+        if (defender instanceof ItemFrame) {
+            if (checkItemFrameProtection(attacker, (ItemFrame) defender)) {
+                event.setCancelled(true);
+                return;
             }
         }
 
@@ -451,6 +445,11 @@ private void onEntityDamageByProjectile(EntityDamageByEntityEvent event) {
                     }
                 }
             }
+        } else if (defender instanceof ItemFrame) {
+            if (checkItemFrameProtection(attacker, (ItemFrame) defender)) {
+                event.setCancelled(true);
+                return;
+            }
         }
 
     }
@@ -1003,4 +1002,41 @@ public void tryCancelPVPEvent(final Player attackingPlayer, final Player defendi
             event.setCancelled(true);
         }
     }
+
+    /**
+     * Checks regions and config settings to protect items from being knocked
+     * out of item frames.
+     * @param attacker attacking entity
+     * @param defender item frame being damaged
+     * @return true if the event should be cancelled
+     */
+    private boolean checkItemFrameProtection(Entity attacker, ItemFrame defender) {
+        World world = attacker.getWorld();
+        ConfigurationManager cfg = plugin.getGlobalStateManager();
+        WorldConfiguration wcfg = cfg.get(world);
+        if (wcfg.useRegions) {
+        // bukkit throws this event when a player attempts to remove an item from a frame
+            RegionManager mgr = plugin.getGlobalRegionManager().get(world);
+            if (attacker instanceof Player) {
+                Player player = (Player) attacker;
+                LocalPlayer localPlayer = plugin.wrapPlayer(player);
+                if (!plugin.getGlobalRegionManager().hasBypass(player, world)
+                        && !mgr.getApplicableRegions(defender.getLocation())
+                                .canBuild(localPlayer)) {
+                    player.sendMessage(ChatColor.DARK_RED + "You don't have permission for this area.");
+                    return true;
+                }
+            } else {
+                if (!plugin.getGlobalRegionManager().allows(
+                        DefaultFlag.ENTITY_ITEM_FRAME_DESTROY, defender.getLocation())) {
+                    return true;
+                }
+            }
+        }
+        if (wcfg.blockEntityItemFrameDestroy && !(attacker instanceof Player)) {
+            return true;
+        }
+        return false;
+    }
+
 }