diff --git a/CODEOWNERS b/CODEOWNERS
index 1455643550..384db8098f 100644
--- a/CODEOWNERS
+++ b/CODEOWNERS
@@ -246,6 +246,7 @@ esphome/components/sdm_meter/* @jesserockz @polyfaces
 esphome/components/sdp3x/* @Azimath
 esphome/components/selec_meter/* @sourabhjaiswal
 esphome/components/select/* @esphome/core
+esphome/components/sen0321/* @notjj
 esphome/components/sen21231/* @shreyaskarnik
 esphome/components/sen5x/* @martgras
 esphome/components/sensirion_common/* @martgras
diff --git a/esphome/components/sen0321/__init__.py b/esphome/components/sen0321/__init__.py
new file mode 100644
index 0000000000..458ffa67f9
--- /dev/null
+++ b/esphome/components/sen0321/__init__.py
@@ -0,0 +1 @@
+CODEOWNERS = ["@notjj"]
diff --git a/esphome/components/sen0321/sen0321.cpp b/esphome/components/sen0321/sen0321.cpp
new file mode 100644
index 0000000000..7801c8c389
--- /dev/null
+++ b/esphome/components/sen0321/sen0321.cpp
@@ -0,0 +1,36 @@
+#include "sen0321.h"
+#include "esphome/core/log.h"
+#include "esphome/core/hal.h"
+
+namespace esphome {
+namespace sen0321_sensor {
+
+static const char *const TAG = "sen0321_sensor.sensor";
+
+void Sen0321Sensor::setup() {
+  ESP_LOGCONFIG(TAG, "Setting up sen0321...");
+  if (!this->write_byte(SENSOR_MODE_REGISTER, SENSOR_MODE_AUTO)) {
+    ESP_LOGW(TAG, "Error setting measurement mode.");
+    this->mark_failed();
+  };
+}
+
+void Sen0321Sensor::update() { this->read_data_(); }
+
+void Sen0321Sensor::dump_config() {
+  ESP_LOGCONFIG(TAG, "DF Robot Ozone Sensor sen0321:");
+  LOG_I2C_DEVICE(this);
+  if (this->is_failed()) {
+    ESP_LOGE(TAG, "Communication with sen0321 failed!");
+  }
+  LOG_UPDATE_INTERVAL(this);
+}
+
+void Sen0321Sensor::read_data_() {
+  uint8_t result[2];
+  this->read_bytes(SENSOR_AUTO_READ_REG, result, (uint8_t) 2);
+  this->publish_state(((uint16_t) (result[0] << 8) + result[1]));
+}
+
+}  // namespace sen0321_sensor
+}  // namespace esphome
diff --git a/esphome/components/sen0321/sen0321.h b/esphome/components/sen0321/sen0321.h
new file mode 100644
index 0000000000..3bb3d5b015
--- /dev/null
+++ b/esphome/components/sen0321/sen0321.h
@@ -0,0 +1,35 @@
+#pragma once
+
+#include "esphome/core/component.h"
+#include "esphome/components/sensor/sensor.h"
+#include "esphome/components/i2c/i2c.h"
+
+// ref:
+// https://github.com/DFRobot/DFRobot_OzoneSensor
+
+namespace esphome {
+namespace sen0321_sensor {
+// Sensor Mode
+// While passive is supposedly supported, it does not appear to work reliably.
+static const uint8_t SENSOR_MODE_REGISTER = 0x03;
+static const uint8_t SENSOR_MODE_AUTO = 0x00;
+static const uint8_t SENSOR_MODE_PASSIVE = 0x01;
+static const uint8_t SET_REGISTER = 0x04;
+
+// Each register is 2 wide, so 0x07-0x08 for passive, or 0x09-0x0A for auto
+// First register is high bits, next low.
+static const uint8_t SENSOR_PASS_READ_REG = 0x07;
+static const uint8_t SENSOR_AUTO_READ_REG = 0x09;
+
+class Sen0321Sensor : public sensor::Sensor, public PollingComponent, public i2c::I2CDevice {
+ public:
+  void update() override;
+  void dump_config() override;
+  void setup() override;
+
+ protected:
+  void read_data_();
+};
+
+}  // namespace sen0321_sensor
+}  // namespace esphome
diff --git a/esphome/components/sen0321/sensor.py b/esphome/components/sen0321/sensor.py
new file mode 100644
index 0000000000..ee613dc440
--- /dev/null
+++ b/esphome/components/sen0321/sensor.py
@@ -0,0 +1,34 @@
+import esphome.codegen as cg
+import esphome.config_validation as cv
+from esphome.components import i2c, sensor
+from esphome.const import (
+    ICON_CHEMICAL_WEAPON,
+    UNIT_PARTS_PER_BILLION,
+    STATE_CLASS_MEASUREMENT,
+)
+
+CODEOWNERS = ["@notjj"]
+DEPENDENCIES = ["i2c"]
+
+sen0321_sensor_ns = cg.esphome_ns.namespace("sen0321_sensor")
+Sen0321Sensor = sen0321_sensor_ns.class_(
+    "Sen0321Sensor", cg.PollingComponent, i2c.I2CDevice
+)
+
+CONFIG_SCHEMA = (
+    sensor.sensor_schema(
+        Sen0321Sensor,
+        unit_of_measurement=UNIT_PARTS_PER_BILLION,
+        icon=ICON_CHEMICAL_WEAPON,
+        accuracy_decimals=1,
+        state_class=STATE_CLASS_MEASUREMENT,
+    )
+    .extend(cv.polling_component_schema("60s"))
+    .extend(i2c.i2c_device_schema(0x73))
+)
+
+
+async def to_code(config):
+    var = await sensor.new_sensor(config)
+    await cg.register_component(var, config)
+    await i2c.register_i2c_device(var, config)
diff --git a/tests/test1.yaml b/tests/test1.yaml
index b78407069d..33782dbf53 100644
--- a/tests/test1.yaml
+++ b/tests/test1.yaml
@@ -1081,6 +1081,11 @@ sensor:
     ambient_pressure_compensation: 961mBar
     temperature_offset: 4.2C
     i2c_id: i2c_bus
+  - platform: sen0321
+    name: Workshop Ozone Sensor
+    id: sen0321_ozone
+    update_interval: 10s
+    i2c_id: i2c_bus
   - platform: sgp30
     eco2:
       name: Workshop eCO2