diff --git a/esphome/components/adc/adc_sensor.cpp b/esphome/components/adc/adc_sensor.cpp
index ad9cf29b6f..ca87c8d11f 100644
--- a/esphome/components/adc/adc_sensor.cpp
+++ b/esphome/components/adc/adc_sensor.cpp
@@ -51,8 +51,8 @@ void ADCSensor::setup() {
     }
   }
 
-  // adc_gpio_init doesn't exist on ESP32-C3 or ESP32-H2
-#if !defined(USE_ESP32_VARIANT_ESP32C3) && !defined(USE_ESP32_VARIANT_ESP32H2)
+  // adc_gpio_init doesn't exist on ESP32-S2, ESP32-C3 or ESP32-H2
+#if !defined(USE_ESP32_VARIANT_ESP32C3) && !defined(USE_ESP32_VARIANT_ESP32H2) && !defined(USE_ESP32_VARIANT_ESP32S2)
   adc_gpio_init(ADC_UNIT_1, (adc_channel_t) channel_);
 #endif
 #endif  // USE_ESP32