diff --git a/api/v2.0/swagger.yaml b/api/v2.0/swagger.yaml
index 54e808400..3da7a7251 100644
--- a/api/v2.0/swagger.yaml
+++ b/api/v2.0/swagger.yaml
@@ -299,6 +299,29 @@ paths:
           $ref: '#/responses/404'
         '500':
           $ref: '#/responses/500'
+  /projects/{project_name}/repositories/{repository_name}/artifacts/{reference}/scan:
+    post:
+      summary: Scan the artifact
+      description: Scan the specified artifact
+      tags:
+        - artifact
+      operationId: scanArtifact
+      parameters:
+        - $ref: '#/parameters/requestId'
+        - $ref: '#/parameters/projectName'
+        - $ref: '#/parameters/repositoryName'
+        - $ref: '#/parameters/reference'
+      responses:
+        '202':
+          $ref: '#/responses/202'
+        '401':
+          $ref: '#/responses/401'
+        '403':
+          $ref: '#/responses/403'
+        '404':
+          $ref: '#/responses/404'
+        '500':
+          $ref: '#/responses/500'
   /projects/{project_name}/repositories/{repository_name}/artifacts/{reference}/tags:
     post:
       summary: Create tag
@@ -512,6 +535,12 @@ responses:
       X-Request-Id:
         description: The ID of the corresponding request for the response
         type: string
+  '202':
+    description: Accepted
+    headers:
+      X-Request-Id:
+        description: The ID of the corresponding request for the response
+        type: string
   '400':
     description: Bad request
     headers:
diff --git a/src/server/v2.0/handler/artifact.go b/src/server/v2.0/handler/artifact.go
index c3b212f63..270e905c2 100644
--- a/src/server/v2.0/handler/artifact.go
+++ b/src/server/v2.0/handler/artifact.go
@@ -27,11 +27,13 @@ import (
 	"github.com/goharbor/harbor/src/api/artifact"
 	"github.com/goharbor/harbor/src/api/artifact/abstractor/resolver"
 	"github.com/goharbor/harbor/src/api/repository"
+	"github.com/goharbor/harbor/src/api/scan"
 	"github.com/goharbor/harbor/src/common/rbac"
 	"github.com/goharbor/harbor/src/common/utils"
 	ierror "github.com/goharbor/harbor/src/internal/error"
 	"github.com/goharbor/harbor/src/pkg/project"
 	"github.com/goharbor/harbor/src/pkg/q"
+	v1 "github.com/goharbor/harbor/src/pkg/scan/rest/v1"
 	"github.com/goharbor/harbor/src/server/v2.0/handler/assembler"
 	"github.com/goharbor/harbor/src/server/v2.0/handler/model"
 	operation "github.com/goharbor/harbor/src/server/v2.0/restapi/operations/artifact"
@@ -47,6 +49,7 @@ func newArtifactAPI() *artifactAPI {
 		artCtl:  artifact.Ctl,
 		proMgr:  project.Mgr,
 		repoCtl: repository.Ctl,
+		scanCtl: scan.DefaultController,
 	}
 }
 
@@ -55,6 +58,7 @@ type artifactAPI struct {
 	artCtl  artifact.Controller
 	proMgr  project.Manager
 	repoCtl repository.Controller
+	scanCtl scan.Controller
 }
 
 func (a *artifactAPI) ListArtifacts(ctx context.Context, params operation.ListArtifactsParams) middleware.Responder {
@@ -176,6 +180,30 @@ func (a *artifactAPI) CopyArtifact(ctx context.Context, params operation.CopyArt
 	return operation.NewCopyArtifactCreated()
 }
 
+func (a *artifactAPI) ScanArtifact(ctx context.Context, params operation.ScanArtifactParams) middleware.Responder {
+	if err := a.RequireProjectAccess(ctx, params.ProjectName, rbac.ActionCreate, rbac.ResourceScan); err != nil {
+		return a.SendError(ctx, err)
+	}
+
+	repository := fmt.Sprintf("%s/%s", params.ProjectName, params.RepositoryName)
+	artifact, err := a.artCtl.GetByReference(ctx, repository, params.Reference, nil)
+	if err != nil {
+		return a.SendError(ctx, err)
+	}
+
+	art := &v1.Artifact{
+		NamespaceID: artifact.ProjectID,
+		Repository:  repository,
+		Digest:      artifact.Digest,
+		MimeType:    artifact.ManifestMediaType,
+	}
+	if err := a.scanCtl.Scan(art); err != nil {
+		return a.SendError(ctx, err)
+	}
+
+	return operation.NewScanArtifactAccepted()
+}
+
 // parse "repository:tag" or "repository@digest" into repository and reference parts
 func parse(s string) (string, string, error) {
 	matches := reference.ReferenceRegexp.FindStringSubmatch(s)